Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2018        Go!    
 
 
April 24, Tuesday 2018 6:13 PM       

       HEADLINES: Nurses’ strike called off                                              Petrol, diesel prices go up again                                              Sreejith’s custody death: Family to approach HC seeking CBI probe                                              Mysterious deaths in Pinarayi: Cause of death is aluminium phosphide, mother under custody                                              I’m not VS sympathiser: Sitaram Yechury                                              POCSO Act: Death penalty will be futile, says Justice Shah                                              Siddaramaiah files nomination from Badami                                              Centre defends death by hanging in SC, says far safer and quicker                                              Death toll in Toronto truck collision rises to 10                                              Fire in karaoke bar in China kills at least 18                                              Selective army censorship of press may impact Pak polls                                              US plans to end work permits for spouses of H-1B visa holders                                              IPL '18: Kings XI Punjab prevail as DD continue to lose                                              Barcelona Open: Bopanna-Vasselin look for winning start                                              Zverer surges to 3rd spot, Nadal stays top in ATP rankings                                              Tendulkar recalls 'happy dents' of World Cup triumph                                              Kaumudi Facebook
       SCI&TECH Next Article: Scientists discover enormous reserves of mercury in permafrost  
       This drug could reverse alcohol's damaging effects on brain
 
         Posted on :17:31:29 Feb 9, 2018
   
A A
       Last edited on:17:31:29 Feb 9, 2018
         Tags: Tandospirone reverse alcohol's damaging effe
 

WASHINGTON DC: Scientists have found a new pill that could reverse the effects of binge drinking on the brain.

The studies of Queensland University of Technology (QUT) researchers in adult mice show that two weeks of daily treatment with the drug tandospirone reversed the effects of 15 weeks of binge-like alcohol consumption on neurogenesis - the ability of the brain to grow and replace neurons (brain cells).

This is the first time tandospirone has be shown to reverse the deficit in brain neurogenesis induced by heavy alcohol consumption.

Tandospirone acts selectively on a serotonin receptor (5-HT1A).

The researchers also showed in mice that the drug was effective in stopping anxiety-like behaviours associated with alcohol withdrawal, and this was accompanied by a significant decrease in binge-like alcohol intake.

"This is a novel discovery that tandospirone can reverse the deficit in neurogenesis caused by alcohol," said study leader neuroscientist Professor Selena Bartlett from QUT's Institute of Health and Biomedical Innovation.

"We know that with heavy drinking you are inhibiting your ability to grow new neurons, brain cells. Alcohol is specifically very damaging for neurons.”

"Other studies in mice have shown that tandospirone improves brain neurogenesis, but this is the first time it has been shown that it can totally reverse the neurogenic deficits induced by alcohol.

"This opens the way to look at if neurogenesis is associated with other substance-abuse deficits, such as in memory and learning, and whether this compound can reverse these."

Professor Bartlett, who is based at the Translational Research Institute, said the discovery by study co-authors QUT postdoctoral research fellows Dr. Arnauld Belmer and Dr. Omkar Patkar came about serendipitously after research started in a different direction.

"It was surprising, and exciting," Dr. Belmer said.

"This drug is relatively new and available only in China and Japan. It is commonly used there and shown to be highly effective in treating general anxiety and well tolerated with limited adverse effects."

Professor Bartlett said researchers are constantly looking at new treatment strategies for alcohol abuse and addiction, which is characterised by extended periods of heavy alcohol use, binges and abstinence, and anxiety and depression which contribute to relapse.

"This is not just another drug that shows promise in helping to reduce binge drinking," she said.

"While it could possibly have that effect, it might be able to help reboot the brain and reverse the deficits the alcohol abuse causes - both the inhibition to the brain's ability to regenerate, and the behavioural consequences that come from what alcohol is doing to the brain, like increases in anxiety and depression."

The findings have been published in Scientific Reports.

A A
       SCI&TECH
Next Article: Scientists discover enormous reserves of mercury in permafrost
 
 
SCI&TECH HEADLINES
PMSing? Could be because of alcohol!  
Social media firms given a week to better protect kids  
The stronger you are, the healthier your brain is  
NASA may soon identify 2,400 alien planets  
What triggers depression among adults?  
Turn your hobbies into part-time job opportunities with these apps  
Apple launches special RED Edition for iPhone 8, 8 Plus  
Humanity’s first flight to Sun to launch in July: NASA  
This World Health Day, let's focus on eye health  
Are babies being introduced to solid food too soon?  
New organ found in human body, could help understand spread of cancer  
Audio-enabled autoplay videos will soon be blocked on Google Chrome  
China hospital to employ AI to address doctor shortage  
A new ray of hope for breast cancer patients!  
Here is how you can travel smart using these apps!  
5 most important aspects of our lives driven by technology  
This telehealth program offers hope for diabetics  
New habitable planet found near our solar system  
Going light with the new Light Phone 2  
What will happen to this beautiful blue planet?  
Liver cancer: New method identifies splicing biomarkers  
Astronomers reveal secrets of most distant supernova ever detected  
Ensuring sexual, reproductive health for overall well-being  
WeChat gets popular in Bhutan: report  
Celebrate love this Valentine's Day with Google Pixel 2  
 
Do you agree with setting age limits for giving death penalty to rapists?
yes
 
no
 
no opinion
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy