Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2012        Go!    
 
 
January 20, Saturday 2018 5:06 AM       

       HEADLINES: Why we need these MPs to talk only in channels, asks K Surendran                                              Hartal in Kannur on Saturday                                              B Sandhya removed as ADGP, South                                              Was son killed over property dispute? Police unwilling to accept Jaya's statement                                              CBI will probe Sreejiv’s death, order passed                                              Fire breaks out in Mumbai's Navrang Studio                                              Solution to SC judges’ row likely on Monday                                              EC has never touched this low: AAP                                              Hafiz Saeed should be prosecuted: US                                              India should not comment on Chinese construction in Doklam: Beijing                                              Pak-Iran to resume rail services                                              Kulbhushan Jadhav abducted from Iran: Baloch activist                                              Brazil legend Pele collapses with exhaustion                                              ICC U-19 WC: India thrash Zimbabwe to top Group B                                              We will definitely try to get Ashwin back in CSK: Dhoni                                              AIFF U-16 team departs for exposure trip to Dubai                                              Kaumudi Facebook
       SCI&TECH Next Article: Indian-American teen wins top science award worth USD 250,000  
       First patient cured of rare blood disorder'
 
         Posted on :22:01:59 Mar 21, 2017
   
A A
       Last edited on:22:01:59 Mar 21, 2017
         Tags: First patient cured of rare blood disorder'
 
WASHINGTON: In a first, doctors in the US claim to have successfully cured an adult patient with a rare blood disorder in which the body does not produce enough red blood cells, causing progressive organ damage and early death. Physicians employed a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant to cure the patient with congenital dyserythropoietic anemia (CDA).
 
The transplant technique is unique, because it allows a donor's cells to gradually take over a patient's bone marrow without using toxic agents to eliminate a patient's cells prior to the transplant, researchers said. Damiano Rondelli, Professor at the University of Illinois at Chicago in US, said the protocol can be used even in patients with a long history of disease and some organ damage because of the minimal use of chemotherapy.
 
"For many adult patients with a blood disorder, treatment options have been limited because they are often not sick enough to qualify for a risky procedure, or they are too sick to tolerate the toxic drugs used alongside a standard transplant," said Rondelli. "This procedure gives some adults the option of a stem cell transplant which was not previously available," Rondelli said.
 
For more than 30 years, David Levy's only course of treatment for CDA was regular blood transfusions to ensure his organs and tissues received enough oxygen. Levy, from Northbrook, Illinois, was 24 when the pain became so severe he had to withdraw from graduate school. By age 32, Levy required transfusions every two to three weeks; had lost his spleen; had an enlarged liver; and was suffering severely from fatigue, heart palpitations and iron poisoning, a side effect of regular blood transfusions.
 
Rondelli said that because of Levy's range of illnesses and inability to tolerate chemotherapy and radiation, several institutions had denied him the possibility of a stem cell transplant. Rondelli performed Levy's transplant in 2014. "The transplant was hard, and I had some complications, but I am back to normal now," said Levy, now 35. "I still have some pain and some lingering issues from the years my condition was not properly managed, but I can be independent now. That is the most important thing to me," he said.
 
Rondelli said the potential of this approach to stem cell transplantation is very promising. "The use of this transplant protocol may represent a safe therapeutic strategy to treat adult patients with many types of congenital anemias - perhaps the only possible cure," Rondelli added. The case report was published in the journal Bone Marrow Transplantation. In a first, doctors in the US claim to have successfully cured an adult patient with a rare blood disorder in which the body does not produce enough red blood cells, causing progressive organ damage and early death. Physicians employed a technique that avoids the use of high-dose chemotherapy and radiation in preparation for a stem cell transplant to cure the patient with congenital dyserythropoietic anemia (CDA).
 
The transplant technique is unique, because it allows a donor's cells to gradually take over a patient's bone marrow without using toxic agents to eliminate a patient's cells prior to the transplant, researchers said. Damiano Rondelli, Professor at the University of Illinois at Chicago in US, said the protocol can be used even in patients with a long history of disease and some organ damage because of the minimal use of chemotherapy.
 
"For many adult patients with a blood disorder, treatment options have been limited because they are often not sick enough to qualify for a risky procedure, or they are too sick to tolerate the toxic drugs used alongside a standard transplant," said Rondelli. "This procedure gives some adults the option of a stem cell transplant which was not previously available," Rondelli said.
 
For more than 30 years, David Levy's only course of treatment for CDA was regular blood transfusions to ensure his organs and tissues received enough oxygen. Levy, from Northbrook, Illinois, was 24 when the pain became so severe he had to withdraw from graduate school. By age 32, Levy required transfusions every two to three weeks; had lost his spleen; had an enlarged liver; and was suffering severely from fatigue, heart palpitations and iron poisoning, a side effect of regular blood transfusions.
 
Rondelli said that because of Levy's range of illnesses and inability to tolerate chemotherapy and radiation, several institutions had denied him the possibility of a stem cell transplant. Rondelli performed Levy's transplant in 2014. "The transplant was hard, and I had some complications, but I am back to normal now," said Levy, now 35. "I still have some pain and some lingering issues from the years my condition was not properly managed, but I can be independent now. That is the most important thing to me," he said.
 
Rondelli said the potential of this approach to stem cell transplantation is very promising. "The use of this transplant protocol may represent a safe therapeutic strategy to treat adult patients with many types of congenital anemias - perhaps the only possible cure," Rondelli added. The case report was published in the journal Bone Marrow Transplantation. 
A A
       SCI&TECH
Next Article: Indian-American teen wins top science award worth USD 250,000
 
 
SCI&TECH HEADLINES
Secret of longevity protein revealed!  
Absence of this gene can give men deadly cancer  
Soon, you can demote group admins on WhatsApp  
Regular yoga can slow down ageing of brain: Study  
What are haemorrhoids (piles) and what causes them?  
WhatsApp facilitates quick switch from voice to video call  
The Thin and Light Lenovo Ideapad 720s shines at Digit Zero 1 Awards  
Frequent heartburns up cancer risk in older adults  
Blueberry vinegar can help fight dementia  
iPhones with older batteries will take a hit in performance: Apple  
Eighth planet found in faraway solar system, matching ours  
Google brings a host of new features on Pixel 2  
Scientists turn beer into suitable petrol  
Space gives a sense of humbleness: NASA astronaut  
Researchers discover genes to prolong human life  
Google announces best apps of 2017  
This technology can help to reduce accidents on icy roads  
Yepzon launches in India; promises smart safety solutions  
Soon, you'll be able to control diabetes with your phone  
Turning bacteria into 'world's smallest tape recorders'  
How breastmilk protects babies from food allergy decoded  
Stars among the oldest in our galaxy discovered  
Apple delays release of smart speaker - HomePod  
Owning a dog may add years to your life  
'Textisms' actually add meaning to written words  
 
Do you think even today police resort to third degree torture to prove crime?
yes
 
no
 
no opinion
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy