Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2012        Go!    
 
 
October 18, Wednesday 2017 12:42 PM       

       HEADLINES: CPM prefers Modi to congress: Antony                                              Amit Shah to join 'Janaraksha Yatra' on its last day in Thiruvananthapuram                                              A V Unnikrishnan Namboodiri new Sabarimala melshanthi                                              Scooter rider dies after being run over by lorry                                              Gold worth Rs. 29 lakh seized at Nedumbassery                                              MLA’s house sealed over unpaid loan                                              Taj Mahal built by blood, sweat of Indian labourers: Yogi Adityanath                                              BJP is India's richest party, Congress ranks second, says report                                              Time for Ayurveda-led 'health revolution': Modi                                              Nuclear war may break out at any time: N Korea                                              Panama Papers journo Caruana Galizia killed by Malta car bomb                                              Suicide bombers, gunmen kill 47 in attacks on Afghan forces                                              China to speed up construction of power project in PoK                                              India unlikely to play any 'four-day' Tests in near future                                              It feels like home playing in India: Tim Weah                                              Kumble turns 47, cricket fraternity tweets heartfelt bday wishes                                              Kaumudi Facebook
       WEIRDNEWS Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection  
       Treatment-resistant 'HIV reservoir' cells identified
 
         Posted on :17:52:03 Apr 18, 2017
   
A A
       Last edited on:17:52:03 Apr 18, 2017
         Tags: Treatment-resistant 'HIV reservoir, cells id
 
NEW YORK: In a first, scientists have identified HIV reservoir cells where the virus can persist despite treatment, a finding that may pave the way for new therapies to effectively treat the disease.
 
HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system, researchers said.
 
They found the virus persists in HIV-infected macrophages - large white blood cells found in tissues throughout the body including the liver, lung, bone marrow and brain.
 
"These results are paradigm changing because they demonstrate that cells other than T cells can serve as a reservoir for HIV," said Jenna Honeycutt of University of North Carolina in the US.
 
Researchers demonstrated the ability of tissue macrophages to support HIV replication in vivo in the total absence of human T cells.
 
However, how macrophages would respond to antiretroviral therapy (ART) and whether macrophages represented a reservoir for HIV after treatment were unknown.
 
Using a humanised myeloid-only mouse (MoM) model devoid of T cells, researchers showed that ART strongly suppresses HIV replication in tissue macrophages.
 
Yet when HIV treatment was interrupted, viral rebound was observed in one third of the animals. This is consistent with the establishment of persistent infection in tissue macrophages, researchers said.
 
"The fact that HIV-infected macrophages can persist means that any possible therapeutic intervention to eradicate HIV might have to target two very different types of cells," Honeycutt said.
 
"This is the first report demonstrating that tissue macrophages can be infected and that they respond to antiretroviral therapy," Honeycutt said.
 
"In addition, we show that productively infected macrophages can persist despite ART; and most importantly, that they can reinitiate and sustain infection upon therapy interruption even in the absence of T cells - the major target of HIV infection," she said.
 
The study was published in the journal Nature Medicine. 
A A
       WEIRDNEWS
Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection
 
 
WEIRDNEWS HEADLINES
Bipasha Basu turns down offer to endorse aerated drink!  
Vampires may have been real people with a blood disorder  
When sex robots helped creator spice up his marriage  
Lord Ganesha issued admit card by a Bihar university  
Karnataka: Infants placed on hot coals as part of religious ritual  
Sex robot Samantha breaks down after being molested tech enthusiasts  
Owl feathers may inspire quieter aircraft, turbines  
'Honest' thieves return booty with a piece of advice  
Chhattisgarh: July 1-born girl named 'GST'  
Playing video games makes you a better university student!  
UP minister's guard carries gun during MRI scan, ruins machine  
Saddam tries to get Aadhar card for Bin Laden  
Aussie senator breastfeeds in Parliament  
Pet dogs may help cut stress in kids: study  
Rats, it's now hic hic time in Udaipur!  
Rats drinking alcohol: Bihar police  
Fruit Juice Floods Russian Town After Factory Roof Collapses  
Veg dishes irk groom, bride finds another man  
Book reveals why Jinnah shaved off his moustache  
Treatment-resistant 'HIV reservoir' cells identified  
Kidnapping, forced marriage: Pakistan's Hindu women hope for protection  
Dogs can adopt human perspective to find food: study  
Legal spat in US over parents wanting to name child "Allah"  
Chimp filmed cleaning dead son's teeth for first time  
Mediterranean diet may improve sperm quality: study  
 
Did Janaraksha yatra create road traffic blocks in Thiruvananthapuram city?
yes
 
no
 
don't know
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy