Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2012        Go!    
 
 
April 28, Friday 2017 3:50 PM       

       HEADLINES: Skirmishes at Munnar strike pandal shame to democratic Kerala: Oommen Chandy                                              Munnar skirmish: Police’s attempt to move striking members to hospital failed                                              Delaying Senkumar’s appointment akin to challenging rules of land: Chennithala                                              ‘Collector Bro’ all praise for new education loan repayment scheme                                              Dinakaran case: Delhi Police arrests Hawala operator Naresh                                              Malegaon blast: Col. Purohit moves SC after HC rejects bail                                              SC to hear plea against linking Aadhaar with PAN cards                                              Possibility of major conflict with N Korea: Trump                                              Brilliant Uthappa powers KKR to top of IPL 10                                              Samuels replaces injured de Kock                                              Kapil Dev's wax figure to grace Madame Tussauds Delhi                                              Gujarat Lions dismiss RCB for 134 allout in IPL                                              Kaumudi Facebook
       WEIRDNEWS Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection  
       Treatment-resistant 'HIV reservoir' cells identified
 
         Posted on :17:52:03 Apr 18, 2017
   
A A
       Last edited on:17:52:03 Apr 18, 2017
         Tags: Treatment-resistant 'HIV reservoir, cells id
 
NEW YORK: In a first, scientists have identified HIV reservoir cells where the virus can persist despite treatment, a finding that may pave the way for new therapies to effectively treat the disease.
 
HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system, researchers said.
 
They found the virus persists in HIV-infected macrophages - large white blood cells found in tissues throughout the body including the liver, lung, bone marrow and brain.
 
"These results are paradigm changing because they demonstrate that cells other than T cells can serve as a reservoir for HIV," said Jenna Honeycutt of University of North Carolina in the US.
 
Researchers demonstrated the ability of tissue macrophages to support HIV replication in vivo in the total absence of human T cells.
 
However, how macrophages would respond to antiretroviral therapy (ART) and whether macrophages represented a reservoir for HIV after treatment were unknown.
 
Using a humanised myeloid-only mouse (MoM) model devoid of T cells, researchers showed that ART strongly suppresses HIV replication in tissue macrophages.
 
Yet when HIV treatment was interrupted, viral rebound was observed in one third of the animals. This is consistent with the establishment of persistent infection in tissue macrophages, researchers said.
 
"The fact that HIV-infected macrophages can persist means that any possible therapeutic intervention to eradicate HIV might have to target two very different types of cells," Honeycutt said.
 
"This is the first report demonstrating that tissue macrophages can be infected and that they respond to antiretroviral therapy," Honeycutt said.
 
"In addition, we show that productively infected macrophages can persist despite ART; and most importantly, that they can reinitiate and sustain infection upon therapy interruption even in the absence of T cells - the major target of HIV infection," she said.
 
The study was published in the journal Nature Medicine. 
A A
       WEIRDNEWS
Next Article: Kidnapping, forced marriage: Pakistan's Hindu women hope for protection
 
 
WEIRDNEWS HEADLINES
Veg dishes irk groom, bride finds another man  
Book reveals why Jinnah shaved off his moustache  
Treatment-resistant 'HIV reservoir' cells identified  
Kidnapping, forced marriage: Pakistan's Hindu women hope for protection  
Dogs can adopt human perspective to find food: study  
Legal spat in US over parents wanting to name child "Allah"  
Chimp filmed cleaning dead son's teeth for first time  
Mediterranean diet may improve sperm quality: study  
Sexual harassment at epidemic levels in UK universities: Report  
Oscar statue is worth only USD 10  
Eating less may slow ageing: study  
Saudi prince buys airplane seats to transport 80 falcons (Video)  
Puppies respond more readily to 'baby talk'  
64-yr-old woman becomes oldest mother in China to deliver baby  
Passenger removed from flight after confrontation with Ivanka Trump  
Stressed snakes strike first: study  
500-kg Egyptian woman to visit India soon for surgery  
Caesarean births impacting human evolution: study  
Cyberbullied teen commits suicide in front of family  
Muslim women in US turn to self-defence to combat 'hijab grab'  
'Ape in heels': Racist post about Michelle Obama causes backlash  
Demonetisation: Brisk biz for sex workers accepting big notes  
A twice-divorced Saudi mother of 6 reinterprets Islamic law  
Tipu a monarch, not freedom fighter, observes Karnataka HC  
Jailed terror accused eat biryai for yrs, need fast-track courts: CM  
 
Should Senkumar be reinstated as DGP, law and order?
yes
 
no
 
don't know
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy