Bookmark Kaumudi Online  Bookmark this site  Editor@Kaumudi  |  Marketing  Print Advt rates  |  Calendar 2018        Go!    
 
 
September 23, Sunday 2018 2:06 PM       

       HEADLINES: Franco Mulackal should be subjected to lie detector test, says police                                              Fr. Mathew Manavath raises allegation against Kerala BJP                                              Body of toddler found                                              CM reaches office                                              Fr. Geevarghese defends his decision to join BJP                                              We did not have a choice, says ex-French President Hollande on Reliance getting Rafale offsets                                              “If church try to throw us out, we’ll face it”, say nuns                                              UN Secretary-General to visit India in October                                              Russia warns US it is 'playing with fire' with sanctions                                              Pak PM Imran hits out at India, calls its response "arrogant" for cancelling talks                                              Hasan, Asghar, Rashid fined 15 per cent of their match fees                                              Kaumudi Facebook
       SCI&TECH Next Article: Aspirin a day may keep liver cancer away  
       Suicide molecules may help combat cancer: Study
 
         Posted on :23:38:54 Oct 22, 2017
   
A A
       Last edited on:23:38:54 Oct 22, 2017
         Tags: Suicide molecules may help combat cancer: Stu
 

WASHINGTON DC: A team of researchers has recently found a "suicide molecule" that forces tumours to self-destruct and trigger a fail-safe mechanism that may protect us from cancer.

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a study, the first to identify molecules to trigger a fail-safe mechanism that may protect us from cancer.

According to researchers from Northwestern University, the mechanism -- RNA suicide molecules -- can potentially be developed into a novel form of cancer therapy.

Cancer cells treated with the RNA molecules never become resistant to them because they simultaneously eliminate multiple genes that cancer cells need for survival.

"It's like committing suicide by stabbing yourself, shooting yourself and jumping off a building all at the same time," said lead study author Marcus Peter.

The team discovered sequences in the human genome that when converted into small double-stranded RNA molecules trigger what they believe to be an ancient kill switch in cells to prevent cancer.

He has been searching for the phantom molecules with this activity for eight years.

This study describes the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

Thus began his search for natural molecules coded in the genome that kill cancer.

Peter stated that the kill mechanism would only be active in a single cell the moment it becomes cancerous. It was a needle in a haystack.

But he found them by testing a class of small RNAs, called small interfering (si)RNAs, scientists use to suppress gene activity.

siRNAs are designed by taking short sequences of the gene to be targeted and converting them into double- stranded RNA. These siRNAs when introduced into cells suppress the expression of the gene they are derived from.

Peter found that a large number of these small RNAs derived from certain genes did not, as expected, only suppress the gene they were designed against. They also killed all cancer cells.

His team discovered these special sequences are distributed throughout the human genome, embedded in multiple genes as shown in the study in Cell Cycle.

To test this in a treatment situation, Peter collaborated with Dr Shad Thaxton, associate professor of urology at Feinberg, to deliver the assassin molecules via nanoparticles to mice bearing human ovarian cancer.

In the treated mice, the treatment strongly reduced the tumor growth with no toxicity to the mice, reports the study in Oncotarget.

Importantly, the tumors did not develop resistance to this form of cancer treatment.

"The problem is cancer cells are so diverse that even though the drugs, designed to target single cancer driving genes, often initially are effective, they eventually stop working and patients succumb to the disease," Peter stated.

Most of the advanced solid cancers such as brain, lung, pancreatic or ovarian cancer have not seen an improvement in survival, Peter said.

The research appears in eLife journal.

A A
       SCI&TECH
Next Article: Aspirin a day may keep liver cancer away
 
 
SCI&TECH HEADLINES
Pluto should be reclassified as a planet, reveals study  
Shared responsibility essential for conserving migratory species  
Microsoft releases Speech Corpus for three Indian languages  
Facebook likely to run on 100% renewable energy by 2020  
Can brain suppress the act of revenge?  
Kerala techies launch portal to facilitate relief measures  
Here's what you may not know about H2O  
Alexa will tell you when it has done its homework  
Students recreate horrific atomic bombings of Hiroshima using VR technology  
Study discovers compounds that can reverse cell ageing  
Online interactive courses on AI in trading, first time on internet  
Apple to fix devices damaged by Japan's floods for free  
IT industry should focus on developing new technologies  
Skype adds read receipts to chats  
Mobile app for replacement of transformers in Raj  
Kashmiri students make solar boat for Dal Lake  
NASA prepares to fly probe into Sun's scorching atmosphere  
Yoga helps against non-communicable diseases: WHO  
Spironolactone can help prevent acne: Study  
Older Amazonian forests help regulate global climate  
Goal conflict linked to depressive symptoms  
A new world: Top 10 new species for 2018  
Beat the risk of frailty with healthy heart  
Twitter to hide trolls that hurl abuse: Twitter CEO  
Fortnite is finally coming to Android  
 
Do you agree with Rahul's allegation against Modi over Rafale deal?
yes
 
no
 
no opinion
 
 
 
Home Kerala India World Business Sports Sci&Tech Education Automobile CityNews Movies Environment Letters 
© Copyright keralakaumudi Online 2011  |  Reproduction in whole or in part without written permission is prohibited.
Head Office Address: Kaumudi Buildings, Pettah P.O, Trivandrum - 695024, India.
Online queries talk to Deepu Sasidharan, + 91 98472 38959 or Email deepu[at]kaumudi.com
Customer Service -Advertisement Disclaimer Statement   |  Copyright Policy